Isolation and characterization of new 18-membered macrolides FD-891 and FD-892.
نویسندگان
چکیده
New 18-membered macrolides FD-891 and FD-892 were discovered from the fermentation broth of Streptomyces graminofaciens A-8890 isolated from a soil sample collected at Yamanashi prefecture Japan. They induce morphological changes of HL-60 cells at low concentration below IC50s and have cytocidal activity against in vitro tumor cell lines. FD-891 showed 2 approximately 7 times stronger activity than doxorubicin whereas FD-892 was 20 approximately 100 fold weaker than FD-891 and doxorubicin.
منابع مشابه
Enantioselective total synthesis of FD-891.
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عنوان ژورنال:
- The Journal of antibiotics
دوره 47 11 شماره
صفحات -
تاریخ انتشار 1994